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College football odds, picks, lines for Week 10: Advanced computer model loving Ohio State and Kentucky

The Week 10 college football schedule is loaded with marquee matchups featuring many of the top contenders for the College Football Playoff. In the latest Week 10 college football odds, No. 5 Michigan is favored by 10, down half-a-point from the opening line, against No. 14 Penn State in a Big Ten showdown. And there’s already been line movement in both huge SEC on CBS games. The 3:30 p.m. ET matchup that will determine the East now has No. 6 Georgia listed at -9.5 after opening at -10 against No. 11 Kentucky. And the de facto SEC West title game at 8 p.m. ET now has Alabama listed at -14.5, up a half-point, against No. 4 LSU at Tiger Stadium. With college football odds and lines already on the move, be sure to check out the Week 10 college football picks from SportsLine’s proven model before laying any of your own. 

The SportsLine Projection Model simulates every FBS college football game 10,000 times, and those who have followed it have seen massive returns. Over the past three years, this proprietary computer model has generated a jaw-dropping $4,210 profit for $100 bettors on its top-rated point-spread picks. 

The model made some huge calls in Week 9, including nailing Oklahoma State’s outright upset of No. 6 Texas. It also was all over Georgia (-6.5) covering against Florida and recommended California (+12) against Washington, as well as Kentucky (+7) against Missouri. Anyone who has followed it is way up. 

Now it has simulated every single play of Week 10 and its college football picks are in. One of the Week 10 college football picks the model is recommending: No. 11 Kentucky covers as a 9.5-point home underdog against No. 6 Georgia. 

There’s a lot riding on this matchup, with the winner clinching the SEC East. The model is calling for Georgia to get the victory, but with a spread approaching double-digits, there’s significant value on the Wildcats in what should be a tight battle.

Kentucky’s defense has been its strength this season, coming into Saturday ranked second in the conference. It held a normally high-powered Missouri offense to just 14 points last week, and the model says the Wildcats will limit Georgia’s vaunted rushing attack to around 150 yards Saturday, helping the Wildcats cover in 56 percent of simulations . 

Another one of the top Week 10 college football picks the model loves: No. 8 Ohio State (-17.5) has no issue covering the spread against Nebraska. The Buckeyes got a week off to recover from a huge letdown against Purdue, and all eyes will be on Urban Meyer to see how the embattled head coach responds to rumors that have swirled about his long-term future. 

Nebraska, meanwhile, is showing signs of progress after a disastrous 0-6 start under new head coach Scott Frost. The Cornhuskers have won two straight, but victories over Minnesota and Bethune-Cookman certainly aren’t enough to prove that they’re ready to keep it competitive against a top-tier opponent. 

The model is calling for almost 300 yards of total offense from Ohio State quarterback Dwayne Haskins, while OSU running backs Mike Weber and J.K. Dobbins team up for close to 200 yards on the ground against Nebraska’s defense, which is ranked 11th in the Big Ten against the run. The Buckeyes cover in a whopping 61 percent of simulations, making this a pick you should be all over on Saturday.

The model also has an extremely strong pick for the showdown between No. 1 Alabama and No. 4 LSU, saying one side hits against the spread in 60 percent of simulations, and is calling for a Top 25 team to get stunned on the road by a huge underdog in an upset that will shake up conference standings forever. 

So what college football picks can you make with confidence in Week 10? And what contender gets stunned by a huge underdog? Check out the latest Week 10 college football odds below, and then visit SportsLine to see which teams are winning more than 50 percent of simulations, all from a proven computer model that has returned over $4,000 in profit over the past three seasons.

Nebraska at Ohio State (-17.5, 72.5)
Michigan State at Maryland (+1, 46.5)
Texas A&M at Auburn (-4, 49)
Louisville at Clemson (-38.5, 59.5)
South Carolina at Ole Miss (PK, 66.5)
Iowa at Purdue (-3, 51)
Georgia at Kentucky (+9.5, 43.5)
Florida State at NC State (-7, 54)
West Virginia at Texas (-2, 58)
Tulane at South Florida (-7.5, 59.5)
Boston College at Virginia Tech (+2, 57.5)
Penn State at Michigan (-10, 52.5)
Missouri at Florida (-6, 58)
Utah at Arizona State (+7, 56)
Duke at Miami (-9.5, 51)
Notre Dame at Northwestern (+9.5, 53.5)
UCLA at Oregon (-7.5, 57)
Louisiana Tech at Mississippi State (-23.5, 46.5)
Oklahoma at Texas Tech (+13, 77.5)
Alabama at LSU (+14.5, 53.5)
Stanford at Washington (-10, 47.5)
California at Washington State (-10.5, 51.5)

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